BIO-PHARMA Experts, please take note.

Dissolved Oxygen (DO) is a critical parameter in biopharmaceutical fermentation processes as it directly affects cell growth, product yield, and product quality. Inaccurate DO measurements can lead to suboptimal conditions for cell growth and product formation, impacting the overall process efficiency and product quality.

Microbial growth within the fermenter can interfere with DO sensor readings, leading to inaccuracies. This interference can be particularly problematic in long-duration fermentation runs where microbial growth is more pronounced leading to frustration among biopharma experts.

Due to above reasons DO sensors require regular cleaning, calibration and maintenance even during the batch to ensure accurate measurements. A Retractable Electrode Housing can help you do just that.

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In the realm of industrial processes, precise pH measurement is not just crucial; it's indispensable. As industries evolve and demand more accuracy and efficiency, the significance of online pH measurement becomes increasingly evident.

Online pH measurement offers real-time insights into critical processes, ensuring optimal conditions are maintained and potential issues are swiftly addressed. However, traditional setups often face challenges, particularly in accessibility and maintenance.
 

ONE MORE PROBLEM SOLVED.
It is a common complaint that long Glass Body pH Electrodes break while Installation/Removal and calibration procedures. This is more prominent in Retractable Electrode Housing with longer immersion Lengths.
 
NOT A PROBLEM FOR US...
Dynamic Process Equipment has developed a unique Electrode Mounting Sleeve for SmartDip X01 &SmartDip X05M Models. Now the pH Electrode can be installed safely in the Mounting Sleeve in the Comfortable Place. The whole thing is now a PUSH-FIT and LOCK system. The quickest and easiest installation procedure in the industry.

Accumulation of unwanted materials present in the fermentation medium, such as proteins, cell debris, precipitates, or microbial growth on the sensor surfaces is called fouling of the sensor. It can interfere with their ability to accurately measure parameters such as pH, Dissolved oxygen, etc.

Read about the remedies and how our retractable electrode housing SmartDip 220M can solve this issue of sensor fouling and measurement drift caused by it.

 

Importance of Process Analytical Technology (PAT) in Bio-pharma industry is huge. PAT allows for real-time monitoring and control of critical parameters throughout the manufacturing process, leading to improved product quality, reduced variability, and increased efficiency.

In particular, the implementation of pH and dissolved oxygen (DO) measurements plays a crucial role in ensuring the success of biopharmaceutical processes. These parameters directly impact cell growth, metabolism, and product formation in bioreactors, making them essential for maintaining optimal conditions.

One innovative solution is the integration of Retractable Electrode Housing technology, which simplifies sensor maintenance by enabling easy access to electrodes for calibration and cleaning without interrupting the process, this technology enhances operational efficiency and ensures reliable data collection.

Continuous pH measurement in Active Pharmaceutical Ingredient (API) manufacturing processes offers several benefits, particularly in reagent dosing control for pH adjustment. Here is the case study on the data collected before and after the implementation of Continuous pH Monitoring and Dosing Control system implemented in a API Manufacturing Process.